THROMBOSIS AND HEMOSTASIS Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury
نویسندگان
چکیده
1Department of Anesthesiology, 2Institute for Laboratory Animal Science, and 3Department of Pathology, RWTH Aachen University Hospital, Aachen, Germany; 4Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands; and 5Department of Medical Statistics, RWTH Aachen University Hospital, Aachen, Germany
منابع مشابه
Effects of Fibrinogen Concentrate on Thrombin Generation, Thromboelastometry Parameters, and Laboratory Coagulation Testing in a 24-Hour Porcine Trauma Model
INTRODUCTION In a 24-hour porcine model of liver injury, we showed that fibrinogen supplementation does not downregulate endogenous fibrinogen synthesis. Here we report data from the same study showing the impact of fibrinogen on coagulation variables. MATERIALS AND METHODS Coagulopathy was induced in 20 German land race pigs by hemodilution and blunt liver injury. Animals randomly received f...
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